Day: August 4, 2020

A ascensão de um vereador : Marcello Sciliano

A ascensão de um conselheiro da cidade : Marcello Sciliano? Com ativa atuação parlamentar, já protocolou mais de nove mil ofícios que influenciam de forma benéfica a vida da população carioca. Além disso, criou inúmeros projetos de lei, como a instituição do Patrulhamento Urbano da cidade pela Guarda Municipal- que posteriormente incentivou a criação do Programa Rio + seguro pela Prefeitura-, a regulamentação do trabalho dos mototaxista, a delimitação de área na Lagoa da Barra da Tijuca para a prática de esportes náuticos, entre outros.

Marcello Sciliano nasceu em 1972 no Rio de Janeiro. Antes de ingressar na vida pública, exerceu função como vendedor no comércio e empreendedor no setor da construção civil. Mas foi com sua incansável atuação nas questões sociais, desempenhando desde 1998 diversos trabalhos em projetos sociais de sucesso, que recebeu a honrosa indicação ao Prêmio Nobel da Paz, no ano de 2010, como reconhecimento por sua responsabilidade solidária.

O Time do Vereador Marcello Siciliano acompanhou hoje, 15/07, a Rio Luz na realização de alguns serviços de manutenção na iluminação pública na Av. Isabel Domingues, Vila Tião, Rua Guaxe e toda extensão da Av. Canal do Anil, na Gardênia Azul, uma solicitação recorrente dos moradores da região. O objetivo é deixar o bairro bem iluminada no período noturno, e ao mesmo tempo levar segurança e qualidade de vida à população.

O vereador Marcello Siciliano se reuniu com líderes de diversas comunidades do Rio e o Secretário de Obras, Infraestrutura e Habitação, Sebastião Bruno, na Prefeitura do Rio.

O vereador Marcello Siciliano participou com o Prefeito Marcelo Crivella na reinauguração do Centro Municipal de Saúde (CMS) Hamilton Land, na Avenida Edgard Werneck, Cidade de Deus, na Zona Oeste. A unidade, que atende cerca de 60 mil pessoas da Cidade de Deus e arredores, estava degradada e sem condições de atender com dignidade os moradores locais. “Agradeço à Prefeitura do Rio por atender meu ofício e realizar a reforma geral do local, restabelecendo as condições adequadas para um estabelecimento de saúde. Fico muito feliz em poder trazer mais saúde e dignidade para os moradores da Cidade de Deus” comenta Marcello Sciliano.

O vereador Marcello Siciliano se reuniu com a Guarda Municipal para falar sobre a fiscalização que vem acontecendo em bares e restaurantes. Após produtivas horas de reunião, Marcello Siciliano oficiou ao conselho competente para que novas regras de fiscalização sejam definidas. A intenção do vereador Marcello Siciliano, assim como os representantes da Guarda Municipal, é que devam ser definidas regras de ocupação geral do espaço, demarcando mesas e cadeiras que os cliente poderão utilizar. Sendo assim, se algum cliente descumprir as regras, concluímos que a multa deva ser aplicada ao infrator e não ao estabelecimento. “Esperamos que o ofício seja atendido, tornando assim a fiscalização mais justa e eficiente. Meu muito obrigado à Guarda Municipal por sempre servir ao cidadão do Rio.” diz o vereador Marcello Siciliano

By Society

Bifurcation analysis teaching and other scholar details

Bioinformatics guides and other scholar info? Combinatorial complexity is a central problem when modeling biochemical reaction networks, since the association of a few components can give rise to a large variation of protein complexes. Available classical modeling approaches are often insufficient for the analysis of very large and complex networks in detail. Recently, we developed a new rule-based modeling approach that facilitates the analysis of spatial and combinatorially complex problems. Here, we explore for the first time how this approach can be applied to a specific biological system, the human kinetochore, which is a multi-protein complex involving over 100 proteins.

BackgroundThe Mitotic Spindle Assembly Checkpoint (MSAC) is an evolutionary conserved mechanism that ensures the correct segregation of chromosomes by restraining cell cycle progression from entering anaphase until all chromosomes have made proper bipolar attachments to the mitotic spindle. Its malfunction can lead to cancer.Principle FindingsWe have constructed and validated for the human MSAC mechanism an in silico dynamical model, integrating 11 proteins and complexes. The model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering based on the Template Model, MCC formation, and APC inhibition. Originating from the biochemical reactions for the underlying molecular processes, non-linear ordinary differential equations for the concentrations of 11 proteins and complexes of the MSAC are derived.

Budding yeast asymmetric cell division relies upon the precise coordination of spindle orientation and cell cycle progression. The spindle position checkpoint (SPOC) is a surveillance mechanism that prevents cells with misoriented spindles from exiting mitosis. The cortical kinase Kin4 acts near the top of this network. How Kin4 kinase activity is regulated and maintained in respect to spindle positional cues remains to be established. Here, we show that the bud neck–associated kinase Elm1 participates in Kin4 activation and SPOC signaling by phosphorylating a conserved residue within the activation loop of Kin4. Blocking Elm1 function abolishes Kin4 kinase activity in vivo and eliminates the SPOC response to spindle misalignment. These findings establish a novel function for Elm1 in the coordination of spindle positioning with cell cycle progression via its control of Kin4. Read more details at Multiscale modeling by Bashar Ibrahim.

Cycles are abundant in most kinds of networks, especially in biological ones. Here, we investigate their role in the evolution of a chemical reaction system from one self-sustaining composition of molecular species to another and their influence on the stability of these compositions. While it is accepted that, from a topological standpoint, they enhance network robustness, the consequence of cycles to the dynamics are not well understood. In a former study, we developed a necessary criterion for the existence of a fixed point, which is purely based on topological properties of the network. The structures of interest we identified were a generalization of closed autocatalytic sets, called chemical organizations.

By Science

World attractions, top destinations selection and London airport transfer services

Top travel locations to visit and London airport taxi from AirportTransfersOnline? Turn on your phone : Providing your mobile number is an excellent way of allowing the airport transfer company to get in touch. A good company will text you on your arrival back into the UK to let you know everything is ok and this also means you have the driver details. Airports can be extremely busy places and good proportion of the people there have no idea where things are or how to get to where they want to go. It’s easy to miss your driver, even though they are there and having a means of direct communication makes the process far easier and less stressful.

Prison, palace, treasure vault, observatory, and menagerie: the Tower of London has done it all and it’s one of the top attractions in London. Widely considered the most important building in England, there’s enough to see and do at this World Heritage Site to keep visitors busy for hours. The centerpiece of this Thames-side fortress is the White Tower. Built in 1078 by William the Conqueror, it’s home to amazing exhibits, such as Line of Kings, the world’s oldest visitor attraction, established in 1652 with a remarkable display of royal armor. Other highlights include the impressive Crown Jewels exhibition, classic Yeoman Warder Tours, the Royal Mint, and exhibits and displays regarding prisoners and executions. All told, the Tower of London covers some 18 acres, so there’s a great deal of exploring to do.

Professional airport transfer companies are well aware of the various requirements that their customers might have. That is why they are always well prepared to ensure that their clients do not face any inconvenience. Most driving companies are equipped with years of experience in this field. Any city in the United Kingdom or the rest of Europe has several airports, most of which are located at a distance of about 2 to 4 hours from the main hub of the city’s activity. A good airport transfer service can pick you up from the airport in time and take you to your destination by taking the shortest route possible, thereby avoiding all unnecessary traffic hassles. Thus it can be said that besides reporting to pick you up on time, these service providers also make sure that you reach your hotel at the earliest possible time so that you don’t get late for your meeting or your sightseeing plans.

Not many cities can say they are home to an ancient volcano, but Edinburgh can. Arthur’s Seat, a grassy, rugged peak 351m above sea level, is visible from almost everywhere in the city and is just a short stroll from the Royal Mile in the centre. Head to Holyrood Park to begin your ascent. It’s a relatively easy hike, but it’ll still get your heart pounding. Rest at the top and admire views of Edinburgh Castle, the Scott Monument and beyond. Find extra information at British Airport Transfers.

Hailed as the anti-theme-park, Bewilderwood offers an unplugged experience full of fantasy and adventure. Explore treehouses, zip-wires, rickety bridges and meet some of the mystical creatures who inhabit the woods. Parents are encouraged to find their inner child and get stuck into the adventure too! Located just a 30 minute drive from Glasgow, Loch Lomond Centre offers visitors the chance to see some rare birds of prey in an up-close and personal setting. There are 35 species of birds and plenty of opportunities to meet them and enjoy a hands-on educational experience.

You could also soak up some culture at London museums, visit the Queen at Buckingham Palace, or take the perfect picture with Big Ben, just some of the many iconic places to go in London. The top 10 free London attractions list is based on visitor numbers: start your sightseeing in London now with these popular spots. Don’t miss out on some of London’s best attractions during busy times. Book online to avoid the queues at the top 10 bookable London attractions and get fast-track tickets and easy access to London’s sights. Read more information at https://www.airporttransfersonline.co.uk/.

By Travel