Author: John Concrane

CBD Body And Hand Lotion: Ingredients

In 2001 three groups published the finding that endocannabinoids are likely the retrograde messenger for DSI and DSE in hippocampus and cerebellum (92–94). A general finding is that inhibitory synapses are more sensitive to depolarization-induced suppression of synaptic transmission than excitatory synapses . Mechoulam R., Ben-Shabat S., Hanus L., Ligumsky M., Kaminski N.E., Schatz A.R., Gopher A., Almog S., Martin B.R., Compton D.R., et al. Russo has postulated that several chronic conditions may be due to deficiencies in eCB signaling. PTSD, migraine, Irritable Bowel Syndrome , PTSD, and fibromyalgia are of particular note in this Clinical Endocannabinoid Deficiency Syndrome . Endocannabinoid genes that mutate are known to help create these deficiencies, which helps explain the genetic component of these diseases.

Without CB2 receptors in the endocannabinoid system, CBD oils for pets would not be nearly as effective, if at all. THC makes us feel high by stimulating endocannabinoid receptors in the brain that are involved with regulating serotonin. Others are more useful for stimulating or inhibiting appetite, and some are involved with immune function or the stress response. Many studies, mainly involving animal subjects, have demonstrated how CBD might help to support health conditions such as chronic pain and inflammation by influencing endocannabinoid receptor activity and interacting with neurotransmitters. Endocannabinoids are molecules produced by the body that regulate many neuronal functions.

Δ9-Tetrahydrocannabinol sensitization of the rat brain to direct cholinergic stimulation. Dinh TP, Freund TF, Piomelli D. A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. Cravatt BF, Prospero-Garcia O, Siuzdak G, Gilula NB, Henriksen SJ, Boger DL, Lerner RA. Chemical characterization of a Loxa Beauty family of brain lipids that induce sleep. Consroe P, Mechoulam R. Anticonvulsant and neurotoxic effects of tetrahydrocannabinol stereoisomers. Consroe P, Martin A, Singh V. Antiepileptic potential of cannabidiol analogs. Consroe P. Brain cannabinoid systems as targets for the therapy of neurological disorders.

After hearing about CBD cream reviews, it’s no surprise that many people know of the wellness capabilities of grown hemp. It is best to talk with the medical provider administering the drug test about CBD usage before undergoing the actual test. In rare cases, CBD might lead to a positive drug test if users take heavy dosages daily.

The discovery of endocannabinoids has raised the question of their potential involvement in the physiological control of appetite and energy metabolism. This subject has been the topic of a number of recent reviews (Di Marzo and Matias, 2005; Kirkham, 2005; Sharkey and Pittman, 2005; Pagotto et al., 2006), and only a brief summary is provided here. Similar increases in food intake can be elicited by 2-AG administered systemically or into the nucleus accumbens shell region (Kirkham et al., 2002) or into the lateral hypothalamus . Sites for the orexigenic actions of endocannabinoids in both the hypothalamus and the limbic forebrain suggest their involvement in both the homeostatic and hedonic control of eating (Harrold and Williams, 2003; Vickers and Kennett, 2005).

All these studies, among others, all suggest that CBD could be a potential treatment for the various ailments that dogs suffer from. But without clinical research support, establishing dosing and effectiveness will remain elusive and out of reach. Qualifications for Applying for a Medical Cannabis Card You need to have a medical cannabis card to purchase…

Although the ECS performs a variety of different tasks, it does with the same goal of homeostasis, or the maintenance of a stable internal environment. For many years, scientists didn’t understand why cannabis byproducts affect humans the way they do. In the 1990s, however, an Israeli doctor named Raphael Mechoulam discovered the endocannabinoid system. With his research team, Dr. Mechoulam found natural neurotransmitters, known as endocannabinoids, that are nearly the same as the natural compounds found in cannabis plants. The ECS is made up of endocannabinoids, receptors, and enzymes and provides the body with a vital way of maintaining homeostasis. It makes sure that our cells and systems stay in the Goldilocks zone, where everything is balanced just right.

Your body’s endocannabinoid system plays a crucial role in regulating several vital functions within your body, regardless of if you’re a cannabis consumer or not. Other scientists argue that CBD binds to one or multiple cannabinoid receptors that researchers have yet to discover. In the context of pain, specifically, your endocannabinoid system will release these endocannabinoids to minimize the number of pain signals that your nerve cells send to the sensory pain center in your brain. I’ve tried a ton of CBD supplements over the years, but for deep, restorative sleep, nothing beats Element Health’s Full-Spectrum CBD Oils.

The endocannabinoid receptors are found on just about every cell of the human body. The ECS is present almost everywhere in the body, facilitating regulatory responses across the central nervous system, digestive system, many vital organs and other bodily functions. The two most prominent endocannabinoid receptors are CB1 and CB2 receptors. CB1 receptors can be found in abundance in the brain and central nervous system, while CB2 receptors are mainly linked to the immune system.

The first pathway will be engaged following the stimulation of receptors that activate PLC (e.g., receptors such group I metabotropic glutamate, M1 or M3 muscarinic, orexin A, etc.) will often lead to production of 2-AG. Based on knockout mice data, DAGLα appears to be the isoform responsible for most 2-AG production that is contributes to synaptic plasticity in the adult CNS . Anatomical studies place receptors such as mGluR5 and DAGLα in close proximity to one another in dendritic spines, where can i get delta 8 carts near me apposed to presynaptic CB1 receptors (60–62). While DAGLα seems the dominant 2-AG producing lipase in adult CNS, DAGLβ may contribute to synaptic 2-AG under certain conditions and plays an important role in the generation of 2-AG during immune responses . Insects (Apis mellifera ), Drosophila melanogaster , Gerris marginatus , Spodoptera frugiperda , and Zophobas atratus ) do not contain cannabinoid receptors. No other mammalian neuroreceptor has been found to be lacking in insects.

Press Release: Vapers Rejoice! The CBDistillery Has Joined The Vaping Revolution With The Announcement Of The CBD E-Liquid Tincture Line.

You can think of it like Goldilocks and her three bears — we can’t be too hot, or too cold, but just right. However, while there is a growing body of research available on the effectiveness of CBD in a wide how to use cbd oil drops under tongue range of cases, from anxiety to pain, scientists are finding it more difficult to find out exactly how CBD exerts its influences. Learn how to create a healthy nighttime routine for good sleep habits here.

Ravinet Trillou C, Arnone M, Delgorge C, Gonalons N, Keane P, Maffrand JP, Soubrié P. Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice. Racz I, Bilkei-Gorzo A, Toth ZE, Michel K, Palkovits M, Zimmer quelle huile cbd pour dormir A. A critical role for the cannabinoid CB1 receptors in alcohol dependence and stress- stimulated ethanol drinking. Porter AC, Sauer JM, Knierman MD, Becker GW, Berna MJ, Bao J, Nomikos GG, Carter P, Bymaster FP, Leese AB, et al.

Cannabidiol is the second major cannabinoid found in the Cannabis plant, which doesn’t cause a ‘high’ like THC. Medical results have shown that CBD has zero to minimum negative effects on users. Juicy Fields breaks down everything you need to know about the endocannabinoid system and how cannabis components interact with it.

Ford WR, Honan SA, White R, Hiley CR. Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilator responses in rat isolated hearts. Fernandez-Rodriguez CM, Romero J, Petros TJ, Bradshaw H, Gasalla JM, Gutierrez ML, Lledo JL, Santander C, Fernandez TP, Tomas E, et al. Circulating endogenous cannabinoid anandamide and portal, systemic and renal hemodynamics in cirrhosis. Fernandez-Espejo E, Caraballo I, de Fonseca FR, El Banoua F, Ferrer B, Flores JA, Galan-Rodriguez B. Cannabinoid CB1 antagonists possess antiparkinsonian efficacy only in rats with very severe nigral lesion in experimental parkinsonism. Felder CC, Joyce KE, Briley EM, Mansouri J, Mackie K, Blond O, Lai Y, Ma AL, Mitchell RL. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.

Also, physiological concentrations of endogenous anandamide are at least an order of magnitude lower than the micromolar concentrations required to activate TRPV1 receptors. Compared with the growing body of information on the vascular effects of cannabinoids, less is known about cannabinoid-induced direct cardiac effects. HU-210 also decreased left ventricular developed pressure in isolated perfused rat hearts through CB1 receptor activation (Maslov et al., 2004; Krylatov et al., 2005). Although psychotropic cannabinoids are unlikely Understand The Right Temperature Settings That Best Suits For Vaping Weed  to gain acceptance for the treatment of insomnia, FAAH inhibitors were shown to enhance certain endocannabinoid-mediated behaviors without evidence for addictive properties (Kathuria et al., 2003). The sleep-inducing property of some potent FAAH inhibitors, such as the endogenous lipid 2-octyl γ-bromoacetoacetate (Boger et al., 1998a), could therefore be therapeutically exploited. If this hypothesis is confirmed by future studies, the beneficial effects of CB1/CB2 agonists and FAAH antagonists in AD could be explored.

At the time of discovery, scientists believed that the presence of THC activated cannabinoid receptors. It wasn’t until a few years later that an internally produced chemical called anandamide was discovered. It was there to react with chemicals that our body produces internally. Scientists first thought that the receptors responded to the presence of THC because tetrahydracannabinol and anandamide were similar at the molecular level. Anandamide , also known as the ‘bliss molecule’, binds to the cannabinoid receptors in the brain and body.

A phytocompound is simple another word for ‘plant compound’ and applies to any plant compound from any plant. CBD oil is a natural oil which is extracted from the flowers and leaves of the hemp plant. It is used by people all over the world within wellness and beauty applications. Administered mindfully, even high THC cannabis can be a safe and effective treatment option for “vulnerable” patient groups, including elderly and end of life patients, who often need powerful symptom control and disease management options. In addition to stimulating the appetite, THC has been shown to have numerous medicinal effects. Laboratory derived THC medications have been used for decades by cancer patients due to its extraordinary ability to quell nausea and prevent vomiting, commonly reported side effects of traditional cancer treatments.

McAllister S.D., Christian R.T., Horowitz M.P., Garcia A., Desprez P.-Y. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. Mercati F., Dall’Aglio C., Pascucci L., Boiti C., Ceccarelli P. Identification of cannabinoid type 1 receptor in dog hair follicles. Campora L., Miragliotta V., Ricci E., What Is Sleep Insomnia? Cristino L., Di Marzo V., Albanese F., Frederica della Valle M., Abramo F. Cannabinoid receptor type 1 and 2 expression in the skin of healthy dogs and dogs with atopic dermatitis. Dall’Aglio C., Mercati F., Pascucci L., Boiti C., Pedini V., Ceccarelli P. Immunohistochemical localization of CB1 receptor in canine salivary glands.

The Endocannabinoid System (Ecs): Everything You Need To Know

A study in 2016 by Dr. Stephanie McGrath involving dogs with poorly managed epilepsy and osteoarthritis revealed that 89% of dogs that were given CBD saw a reduction in the frequency of their seizures. CBD SHATTER PRODUCTS AND HOW TO CONSUME THEM CBD products are the talk in town, courtesy of the… Liquid cannabis is very stable, but it can go bad if not stored properly. To ensure your liquid cannabis lasts as long as possible while still being safe to consume, you should store it in a cool cupboard or refrigerator away from direct sunlight. This makes it important to store the product correctly if you are not planning on using it right away!

His four-year course at Pretoria university earned him some work in the hospital. He is a nurse, and he has seen patients suffer, especially when they have cancer symptoms. Luca is a kind-hearted person who always feels sad when people are suffering. That is why he resorts to mass education through his informative articles.

The positive reinforcing effect of natural rewards, such as those derived from eating, drinking, work, or sexual activity, are mediated by the brain’s reward circuitry. Neuroanatomically, this circuitry consists of three series of coupled pathways. First-order neurons project from structures in the ventral limbic forebrain to the mesencephalic ventral tegmental area where they synapse onto dopaminergic neurons. These second-order neurons project primarily to neurons in the shell of the nucleus accumbens , but also to cortical areas and to the amygdala.

Is CBD For Pets Different Than My CBD?

These broad-based targets may underlie the ability of rimonabant to correct symptoms of the metabolic syndrome, as discussed below. They also raise the intriguing possibility that if a CB1 antagonist that does not cross the blood-brain barrier were available, it could be effective in the treatment of the metabolic syndrome without the risk of adverse CNS side effects . Anandamide has been found to be an agonist ligand for the TRPV1 ion channel, although its affinity in the low micromolar range is lower than its affinity for CB1 receptors .

Nano CBD And Nanotechnology – All You Need To Know

However, you could test positive for THC if you consume large quantities of CBD oil. Even if the plant that the CBD oil was derived from contains less than 0.2% THC, that percentage can rise exponentially if you ingest high doses of CBD. The way that CBD is metabolised by your body can interfere with how your body normally metabolises other drugs you take.

Where Can You Buy CBD Oil And What Should You Look For? A CBD Shopping Guide

You’re probably familiar with your body’s immune system or cardiovascular system. But the mechanism through which hemp works hasn’t been understood since quite recently. In the 60s, scientists finally discovered CBD…but that still didn’t explain everything. It wasn’t until the early 90s that cannabis researchers realized CBD was interacting with was ist ein breitspektrum cbd öl a system built into human physiology. Zuardi AW, Shirakawa I, Finkelfarb E, Karniol IG. Action of cannabidiol on the anxiety and other effects produced by Δ9-THC in normal subjects. Wartmann M, Campbell D, Subramanian A, Burstein SH, Davis RJ. The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide.

Cannabinoids are the active compounds in cannabis that physiologically affect users. Along with THC, CBD is one of the most prominent cannabinoids, accounting for up to 40% of cannabis extracts, depending on the plant. Without the ECS to maintain balance, systems of the body begin to malfunction. To think of this relationship, imagine a teacher giving information to her students. If she suddenly starts speaking too fast, the students will ask her to slow down back to a normal pace.

It may result in different reactions at different concentration levels. That’s why MyRemede offers products of varying CBD potencies to help you find the most effective serving size. At 420 Intel we understand that effective marijuana industry news coverage is a constant endeavor.

A 1999 study investigating potency loss in cannabis found that THC converts into CBN as the buds mature and age; this happens due to oxidation. As well, like with any cannabis-derived product, start with small doses to see how your body responds. From there, you can increase your dose of CBN incrementally to fit your specific needs—and you just might see yourself sleeping better, releasing tension, and fighting viruses in the process. Despite the hype, it’s always best to do your homework on CBN’s effects and figure out if the cannabinoid is right for you. And, as always, ask for certificates of third-party analysis, which should verify product quality and potentially harmful additives. As much medicinal potential as this cannabinoid may have, cannabis remains a federally illegal Schedule I substance, and that usually applies to its components as well.

Is the overall action generated by the receptors, endocannabinoids, and enzymes all working in sync throughout the body creating a rhythmic flow that leads to balance in the body. The cannabinoids that we consume and the endocannabinoids that our bodies produce need somewhere to go; that’s where cannabinoid receptors come in. Cannabinoid receptors are designed to bind to cannabinoid receptors and match up like a lock & key. A plant-based cannabinoid that’s gotten a lot of attention from researchers is cannabidiol or CBD.

What Is The Role Of The Endocannabinoid System?

They can slow down their destruction, keeping them in the body longer. Marijuana contains the phytocannabinoids (plant-based cannabinoids) Delta-9 tetrahydrocannabinol and cannabidiol , as well as less potent cannabinoids, terpenes and other compounds. Consuming cannabis, its distillates or synthetic copies of its cannabinoid molecules is the best way to hack your endocannabinoid system. Cannabis-based treatments for anxiety, post-traumatic stress disorder, chronic neuropathic pain, nausea, anorexia, insomnia, irritable bowel disease, arthritis and more have all shown promise in preliminary research.

This process ensures that enzymes, the catalysts for the biochemical reactions constantly occurring within us, can function properly without disruption. When this balance is lost, the systems that keep us healthy can begin to collapse, like a trapeze artist wobbling precariously on a high-wire. The entourage effect is the theory that the various cannabinoids have a more potent effect when used together. Industry experts tend to be big believers in the entourage effect, and also cultivate cannabis with certain cannabinoid ratios in hopes of crafting a unique smoking experience. The science is still unclear, but we’re beginning to see a picture of the way different cannabinoids interact with one another.

You will also find cannabinoids and endocannabinoids at the intersection of different body systems. This allows for coordination and communication between various types of cells. For instance, at an injury site, you will find cannabinoids decreasing the rate at which sensitizers and activators are released.

How Does Cannabis Impact The Endocannabinoids?

The ECS comprises receptors, endocannabinoids, and enzymes, which usually work together to assist maintain stability in certain processes like sleep, mood, and temperature. Every human cell has cannabinoid receptors that form the central nervous system and the peripheral nervous system framework. Endocannabinoids bind on these receptors and send signals to the ECS when action needs to be taken.

More research is needed to understand the role of THCV on the endocannabinoid system in greater detail. A cannabinoid, by definition, is any compound that can interact with the endocannabinoid system. Some directly stimulate the ECS receptors , others bind to it without activating them , and some even block its effects.

CBD has been shown to stop the cravings that opioid addicts have when trying to stop using the horrifically addictive drug responsible for so many deaths. Even people trying to quit using tobacco have done so successfully by using CBD oils to help. Also, while that lipid is floating along, minding its own business, if it sees a long chain of impulses being rapidly sent to the brain, it interrupts them and stops them.

Second, stimulation of immune cells by bacterial toxins such as lipopolysaccharide increases the cellular levels of endocannabinoids and their degrading enzyme. Third, cannabinoid agonists modulate immune function both in vitro and in vivo via cannabinoid receptor-dependent and -independent mechanisms. The role of CB1 receptors in these effects was indicated by the ability of SR to block them and by their absence in CB1 knockout mice (Osei-Hyiaman et al., 2005b). The hepatic lipogenic pathway may be also directly activated through a cannabinoid-induced decrease in AMPK phosphorylation and activity in the liver (Kola et al., 2005). CB1 receptors have been also detected in rat hepatocytes (Michalopoulos et al., 2003), in whole mouse liver (Biecker et al., 2004), and in rat and human hepatic stellate cells (Siegmund et al., 2005; Teixeira-Clerc et al., 2006).

Scientists continue to uncover that its maintenance is essential to homeostasis, the body’s ability to maintain a state of internal balance. Before we get too technical though, let’s start with how and when the ECS was discovered. CB1 receptors, one of the most common receptors Do CBD Gummies Have Thc In Them? in the whole nervous system, are necessary for a successfully functioning brain. These specific brain receptors are also responsible for the psychoactive properties of cannabis when they bind with THC. CB2 receptors are commonly found in the cells of the human immune system.

These effects are probably due to the receptors’ interaction with anandamide and other endocannabinoids, or their connection to it. While anandamide is produced internally, it can be controlled by the existence of phytocannabinoids, which may emphasize its effects on the endocannabinoid system. Scientists are examining the connection between phytocannabinoids and endocannabinoids in hopes of determining the nature of the relationship. Though it’s one of the body’s most crucial systems, it’s also one of the least understood. The endogenous cannabinoid system, also known as the endocannabinoid system or ECS, has recently become the subject of scientific research and more study is needed to learn how these receptors work. Here, we’ll look at the endocannabinoid system and why its study is essential.

The role and importance of the Endocannabinoid system are mentioned in every other CBD or THC article. We know the basics of how CBD affects ECS, and how ECS maintains homeostasis. Let us take a closer look at the functions, importance, and receptors of our Endocannabinoid system. Now that you are familiar with the natural benefits of the two main cannabis compounds – THC and CBD – let’s take a look at how these and other cannabinoids work together to deliver the full potential of cannabis. You have probably heard of neurotransmitters like dopamine and serotonin. They act as chemical messengers of our nervous system, sending messages back and forth between receptors in our body.

Killestein J, Hoogervorst EL, Reif M, Blauw B, Smits M, Uitdehaag BM, Nagelkerken L, Polman CH. Immunomodulatory effects of orally administered cannabinoids in multiple sclerosis. Kadoi Y, Hinohara H, Kunimoto F, Saito S, Goto F. Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats. Kadoi Y, Hinohara H, Kunimoto F, Kuwano H, Saito S, Goto F. Effects of AM281, a cannabinoid antagonist, on systemic haemodynamics, internal carotid artery blood flow and mortality in septic shock in rats. Joyeux M, Arnaud C, Godin-Ribuot D, Demenge P, Lamontagne D, Ribuot C. Endocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts. Joseph J, Niggemann B, Zaenker KS, Entschladen F. Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes. Jin W, Brown S, Roche JP, Hsieh C, Celver JP, Kovoor A, Chavkin C, Mackie K. Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization.

The non-psychoactive compound is capable of influencing people’s mood, appetite, anxiety levels, and pain after consumptions. The expression of the CB2 receptor is primarily through the immune system; specifically, the peripheral nervous system. CB2 receptors are in the brain, but evidence suggests its primary function is to regulate cytokine release, which ensures a healthy defense system. Endocannabinoids interact with either of these receptors, though the effect varies based on location and quantity. These microscopic marvels serve as regulators to maintain appropriate levels for a wide range of bodily functions, including appetite, pain sensation and even memory and libido.

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Top rated infrared neck heating pad manufacturer right now

Shoulder heating pad provider right now? UTK technology is the best infrared heating pad supplier provides wholesale far infrared heating pad online. UTK far infrared heating pads include 3 different series of heating mats. They are natural jade heating mat, tourmaline heating pad and amethyst heating pad. All the infrared heating mats have intelligent controller that can set time and temperature. The natural gemstones can emit far infrared rays and negative ions, which will penetrate deep into the tissues of human body to relieve pain and dicomfort, improve blood circulation, reduce the symptoms of chronic disease, promote metabolism, revitalize skin cells, eliminate impatience and negative mood,accelerate tissue healing and improves overall wellness. UTK heating pad, heating mat, heating belt and heating wrap can be used in back, neck, shoulder, neck and shoulder,waist, feet, knees and the full body. Discover additional information at back and shoulder heating pad.

Far infrared light is the frequency of invisible light that is generated naturally by the sun. FIR Therapy is a type of low energy therapy that takes advantage of the heat generated by waves of energy from the far end of the infrared spectrum. This safe and natural alternative therapy can be used in the treatment of a variety of health problems such as arthritis, muscle pain and spasms and shoulder or joint stiffness. FIR therapy also benefits the body by: Helping the body remove toxins through perspiration; Reducing tension and stress; Improving lymphatic flow; Boosting the immune system; Increasing the circulation of blood deep in the tissues.

European research has shown that negative ions increase collagen production, make cell membranes more permeable, and help strength the immune and autonomic nervous system. Research in Japan has shown that negative ions maintain a balance between insulin and the adrenal functions in the autonomic nervous system, and that negative ionization increases the ions in the calcium and sodium (salt) in the blood and raises its alkalinity. Gamma globulin also increases, creating blood that it rich in proteins as well as antibodies.

It can be applied as many as three seasons a day for up to 30 minutes per session (plus it has no side impacts). They are taking a trip friendly and can be in use with you wherever in the world. The Infrared Heating pads facilitate negative ions for profound sleep and a calming impact on the memory. Pain relaxation: Infrared heating pads assist with pain release. Joint of Bones and muscle pain cure: Far heating pads hold high with bones and tissue pain remedy. Spasm aid: It also helps ease spasm.

By exposing the light to the skins surface the skin’s photoreceptors are activated and let the skin cells absorb the energy. Photon light therapy stimulates your body in a specific way that medication is unable to accomplish. This added benefit gives you more control on a molecular level. Incorporating photon light into your wellness maintenance routine, in addition to FIR and negative ions, will strengthen your body’s ability to fight back against invasive, harmful agents in your life. Negative ions have a relaxing effect and have been reported to normalise your breathing rate, decrease blood pressure and relieve tension. Because negative ions are absorbed directly into the bloodstream they may help to combat harmful free radicals within your body.

Different from traditional electric heating pad, UTK best weighted heating pad is filled with jade & tourmaline beads. These healing stones will heat up faster, up to 159 degrees within seconds to relieve pian. Both jade and tourmaline stones are believed to have calming and soothing properties, reduce anxiety and stress, support the exchange of oxygen in the blood, improve circulation, and help with the disease, liver, skin and autonomic nervous system.The weighted design helps keep the electric heating pad in place, so you don’t have to hold it anymore.The ultra soft flannel cover makes the weighted electric heating pad more comfortable and cozier. It can be used in neck,shoulders, lumbar, knee and cramps. There is weighted heated neck and shoulder wrap which special for neck and shoulder pain relief.

UTK technology specializes in far infrared heating pads, UTK far infrared heating pads are FDA registered as Medical Devices Class II. All UTK far-infrared heating pads use a combination of negative ions, far-infrared rays and natural stones to give you optimum healing. The pads are tested to make sure they contain the highest amount of far-infrared rays and negative ions. All of UTK far-infrared heating pads are free of radiation and EMF. Find extra info on utktechnology.com.

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MaryAnn Holder or the climb of a blockchain-enabled network platform expert

The ascent of a blockchain multiparty network ecosystems consultant : MaryAnn Holder-Browne? MaryAnn Holder on One Network’s Intelligent Control Tower: The Supply Chain Control Tower Value Matrix 2020 from Nucleus Research, provides a snapshot of the market based on how vendors are delivering value to customers through the usability and functionality of their software. Fill out the form on the right to download your complimentary copy of the Control Towers Value Matrix for 2020, and learn what control towers are, how they are transforming supply chains, and what they can do to boost visibility, efficiency and automation in your supply chain.

One Network Enterprises, the global provider of multi-party digital network platform and services, today announced that Gartner, Inc., a leading IT research and advisory firm, has positioned the Company as a Leader in its Magic Quadrant for Multienterprise Supply Chain Business Networks report. According to the report, “Multienterprise supply chain business networks support a community of trading partners — of any tier and type within a network — that need to coordinate and execute supply chain processes across multiple enterprises.”

Multiparty networks have all the key elements missing from blockchain 1.0, including: Scalability – using a scalable grid architecture, multiparty network support tens of thousands of trading partners and the transaction volume that entails. Confidentiality – because they are built using multiparty permissions frameworks with granular and role-based permissions to ensure secure data access. Functionality – by providing powerful, multiparty apps such as logistics management that run on the network and write to a blockchain. Community Master Data Management (MDM) – that manages and synchronizes data across different systems and parties to ensure data is trusted. Combined, these features enable powerful functionality that can support all parties, including buyers, sellers, fulfillment, and logistics partners via a shared app. This allows all parties to transact while showing only the relevant authorized slice of the data to each partner. Discover additional information on MaryAnn Holder-Browne.

The network has over 75,000 participating organizations, allowing customers to find partners and collaborate around their plans. It supports industries in CPG, retail, restaurant and foodservice, healthcare and pharmaceuticals, high tech, aerospace, defense, and government, automotive, and logistics service providers. According to the report, One Network has taken several steps with its planning applications to increase automation and usability for its customers by providing intelligent agents that perform a host of functions such as forecasting, replenishment, sourcing, and transportation optimization. MaryAnn Holder-Browne, Chief Marketing Officer of One Network: “We are thrilled to once again be recognized by Nucleus Research”.

MaryAnn Holder-Browne is Chief Marketing Officer at One Network Enterprises, a provider of the blockchain-enabled network platform, The Real Time Value Network. From inbound supply to outbound order fulfillment and logistics, optimize and automate across your entire supply network and every trading partner. The NEO Platform’s intelligent agent technology delivers predictive and prescriptive analytics with real time information to help you lead your industry – for the highest services levels and product quality at lowest cost.

If we need to find ideas on how to engage all these different audience members especially as technology and people evolve, do you look at other industries and see what they’re doing? That’s a good question because we’re evolving so fast. The landscape is changing really quickly. I think people’s consumption is changing very quickly. We look at a lot of different factors. We’re increasingly a social media world and is very heavily influenced by social media, the characters, and the stars and the tenants of that generation that has been raised on a social media platform. It’s multi-generational so we’re we’re consuming things in smaller sound bytes but that doesn’t mean that the smaller sound bytes can’t something very very applicable and really relevant to what your needs are. We look at the social media world. We look at the music world. We look at the fashion world. B2B, oftentimes, we might get stuck in sort of an ivory tower. But, if you look beyond that into the B2C world how consumers are consuming in the consumer market, it really leads in terms of what the next generation of B2B is going to adopt. You can call it a bullwhip effect.

By Technology

Excellent grinding discs online shopping in the UK in 2022

Best flap discs online store in the UK right now? An angle grinder is an extremely versatile power tool that can be used for a variety of cutting, grinding and polishing jobs. This is why angle grinders are so commonly seen on construction sites and in auto garages and workshops. Angle grinders work by using rapidly rotating headgear to which you can affix a variety of interchangeable abrasive discs or blades. The fast rotation allows these super powerful tools to cut through the most resistant materials, including metal, concrete, and stone. However smaller angle grinders can also be used for more delicate work such as cutting ceramic tiles or polishing metal. Discover extra info on https://www.weldingsuppliesdirect.co.uk/abrasives.html

If you’re looking for a reliable cutting disc that can handle a variety of materials, this tool is a great option. This 10-pack of disc grinder cutting wheels is perfect for cutting metal and stainless steel surfaces. With thin metal cutting discs, you can easily get into tight spaces, and they are durable enough to handle even the toughest jobs. Whether you’re a professional contractor or a DIY enthusiast, these disc grinder cutting wheels are sure to come in handy. It’s made of durable aluminum oxide grains that provide an aggressive cutting action and longer service life. Due to the reinforced double fiberglass mesh, this disc meets the MPA en12413 standard. The Panlen Metal&Stainless Steel Cut-Off Disc for Angle Grinder is the perfect accessory for anyone with a 4.5 inch disc grinder. With this size, the cutting discs reach up to 13,000 RPM and 80M/S speeds. You can cut carbon steel, pipe, iron, copper and all other ferrous metals. It is made from tough abrasive materials, this disc can easily take on even the most challenging projects.

After the WORKPRO grinding wheel, the S SATC cutting wheel is competitively the best. It offers a pack total of 50 best angle grinder discs. Each of the cut-off wheels comes with a 4 ½ -inch diameter and a metal center of 7/8”. The 0.040-inch thickness of the discs increases compatibility with most of the angle grinders out there. SATC Cutting Wheel for Thin Metal & Stainless Steel Additionally, the S SATC cut-off wheels are appreciatingly long-lasting because of their building materials. You certainly do not want to miss the discs that are made of grains of aluminum oxide resinoid-bond. Also, the proprietary hard bond matrix makes a great combination. The materials make the discs aggressive enough to cut through any tubes, pipes, stainless steel, metals, or alloys. With a fast and consistent cutting delivery, the cutting wheels retain a higher cut-rate throughout their life.

Metal cutting blade for angle grinder is a must-have tool for many professions. If you are looking to buy a metal cutting blade for an angle grinder, then please read on. With so many brands and models to choose from, it can be hard to know which one is the right choice for a project. We hope this review will make your decision easier. If you’re looking for a quality metal cutting wheel for your angle grinder, look no further than PEGATEC’s Cutoff Wheels. The cutting wheel is specially designed for general purpose metal cutting, making it the perfect tool for the job. Since the design of this product starts from top-grade raw materials and includes 0.04in ultra-thin thickness, you can optimize the performance of the metal cutting wheels.

Angle grinders are formidable tools and need plenty of power to spin cutting or grinding discs at high velocity. Look for corded angle grinders that spin between 11,000-12,000 rpm or cordless angle grinders that spin between 7,500-9,000 rpm. The best angle grinder should be powered by a 700W motor at minimum if corded or, if cordless, an 18V battery that has a capacity of at least 4Ah. The grinding wheel diameter on most angle grinders is usually 115-125 mm, although heavy-duty angle grinders can accommodate grinding tools over twice that size. Noise and vibration levels are important aspects to consider with this type of power tool. Often the best angle grinders are the least noisy with lower vibration levels. This is especially so with cordless versions with brushless motors but they are more expensive, particularly if you include the cost of a battery and charger. Explore a few more details at https://www.weldingsuppliesdirect.co.uk/.

By Industrial

Nanocrystalline transformer core supplier today

Nanocrystalline cores supplier today? Transmart Industrial’s nanocrystalline core series include multiple types , For example, nanocrystalline cut cores,nanocrystalline toroidal cores,nanocrystalline tape wound cores,nanocrystalline powder cores, etc.Good materials, advanced production technology, and fine manufacturing techniques are used in the production of nanocrystalline core. Transmart nanocrystalline core suppliers & manufacturers designs transformer core material with to keep it outstanding among similar products. Find additional info on nanocrystalline cores. As we focus on the improvement of the quality, this product has been manufactured with high quality and stable performance. It is of fine workmanship and good quality and is well sold in the domestic market. A positive market response indicates that the product has a good market prospect.

As for why it can boost and depressurize It needs to be explained by Lenz’s law The magnetic flux generated by the induced current always hinders the change of the original magnetic flux. When the original magnetic flux increases, the magnetic flux generated by the induced current is opposite to the original magnetic flux. In other words, the induced flux generated by the secondary winding is opposite to the main flux generated by the original winding, so the secondary winding has a low-level alternating voltage. So The iron core is the magnetic circuit part of the transformer The winding is the circuit part of the transformer.

The common mode inductor using nanocrystalline core material can well suppress the peak voltage, protect sensitive components, and reduce the motor shaft voltage. Because of the unique characteristics of nanocrystalline core, it has been well used in some high-power system industries. Electric energy meter, power meter, ammeter, electric measuring equipment and other instrument fields. Various power current transformers in power transmission and distribution monitoring system. Leakage protection, relay protection, servo motor protection, fire monitoring, etc Current and voltage data sampling, etc.

Silicon steel is a traditional magnetic material mainly for 50Hz to 1000Hz electronic and electrical applications. The toroidal core is one of the main products of Transmart Industrial. Our silicon steel core series has many styles to meet the diversified needs of customers. We manufacture various type of cores in silicon steels, such as Current Sensor Cores, silicon steel transformer core, Instrument Transformer Cores, Torodal cores, C-cores, Unicore etc. Transmart Industrial carries out strict quality monitoring and cost control on each production link of toroidal core, from raw material purchase, production and processing and finished product delivery to packaging and transportation. This effectively ensures the product has better quality and more favorable price than other products in the industry. Discover more information at https://www.transmart.net/.

It is worth noting that Japan is vigorously developing FEMB amorphous alloy and nanocrystalline alloy. Its BS can reach 1.7 ~ 1.8T, and the loss is less than 50% of the existing FeSiB Amorphous Alloy. If it is used in power frequency electronic transformer, the working magnetic flux density can reach more than 1.5T, while the loss is only 10% ~ 15% of silicon steel power frequency transformer, it will be a more powerful competitor of silicon steel power frequency transformer. Japan is expected to successfully trial produce FEMB amorphous alloy power frequency transformer and put it into production in 2005.

Nanocrystalline magnetic core is a new type of soft magnetic material with high BS, high effective permeability, high DC bias stability, high temperature stability, wide frequency adaptability, low power consumption and low cost. It is applied to high-power, high-frequency, miniaturized and high conversion switching power transformer and choke. At present, the solar energy industry inverter, water energy, air energy, electric energy conversion and charging of hybrid vehicles have great market space and future, because the performance of nanocrystalline magnetic core is highly controllable.

By Industrial

Kitchen remodel company Canyon Country

Premium kitchen remodel contractors Canyon Country, CA? With over 40 years of experience, our team holds each project to the high standards we have set for ourselves. You can rest knowing your home renovation is in great hands with the team at Randal G. Winter Construction, Inc. Additions and remodels are a personal experience, as it requires the client to allow our team into the home they already inhabit on a daily basis through the duration of the project. We pride ourselves on maintaining high standards of service and skilled artisans for each craft. All the professionals you need for a home remodel or addition are available on our team. Our goal is to get the job done right and make the construction process less stressful for you and your family. Read more about our process and set up an appointment to discuss your remodel vision! Read even more details at kitchen remodel Canyon Country.

Both granite and marble are heat-resistant. Both types of stones were formed through heat, either through volcanic activity or enormous amounts of heat and pressure. Typically, hot pots will not bother either stone, and neither will discolor when used near heat. Always use caution with hot pots in the kitchen, regardless of how well your stone handles the heat. Decomposing granite, which is found in soil, has been known to give off radon 2 gas. So naturally, some people are concerned about using granite counters in their home. There is no evidence, however, that either granite or marble slabs give off radon 2 gas in the home. If you are concerned, radon 2 test kits are available, which can detect the gas.

I love the look of light tile and dark grout, but when we built I had everything put in white on white. Staining the grout dark is a simple and easy way to mimic the modern, international look of classic subway tile. I’ve done this at our home, and loved the results. I had no idea that there were so many simple yet dramatic DIY bathroom upgrades besides the standard switching textiles and painting the walls. These do-it-yourself projects make a big impact by upgrading the fixtures, hardware, and whole landscape of the bathroom—you can even do all five in just one weekend!

Reactivity to Acidic substance: Both natural stones have a porous structure but the metamorphic attributes of marble makes it more porous and therefore marble is easily stained from spills especially from liquids that are acidic in nature like fruit juices and wines. On the other hand, granite is much more resilient towards stains as long as an effective sealant is maintained on the surface liquid spills will not permeate into the surface.

A marble countertop in a kitchen where cooking happens won’t always look pristine, no matter how well you maintain it. But that’s part of the beauty of natural stone, says Bruno; over the years it acquires a patina that lends character, and many people consider that an asset. But there are still some things you can do to protect and preserve it. We asked Bruno for his advice on the best way to care for a marble countertop. Start with a good sealant. “Marble is one of the more porous stones, so you have to protect the surface by keeping it well sealed,” says Bruno. “When you buy the countertop, there’s no sealant on it. You could ask the installer to apply the sealant, but you can easily do it yourself once the countertop is in place.”

When renovating a property it can sometimes be tempting to give heavily advertised ‘miracle cure’ treatments a try, lured by extraordinary claims such as ‘never paint again’, ‘seal leaks for good — instantly’ or ‘the ultimate solution to all roofing problems’. But some of these products can actually be very damaging when applied to older buildings. Spray-on renders and polyurethane foams can block crucial ventilation paths in walls and roofs, and despite claims to the contrary offer virtually zero insulation benefits. Instant damp sealants are rarely effective and can trap damp in walls. Basically, if something sounds too good to be true, it probably is.

Randal G. Winter founded Randal G Winter Construction in 1980 and has spent over 35 years in the construction industry as a Licensed General Contractor. He holds licenses in eight different trades including: Concrete, Drywall, Electrical, Landscaping, Painting, Plumbing, Tile and Asbestos. Sean Himes began his journey with Randal G. Winter Construction, Inc. in 2009 and after three years left to garner additional experience in the construction industry. He returned to Randal G. Winter Construction as Project Manager in February 2016. Sean’s responsibilities include coordinating and running all aspects of a project, which includes Randal G. Winter Construction Employees and Subcontractors. See additional details at https://www.rgwinter.com/.

By Home

Top toenail fungus medicine right now

Top toenail fungus treatment in 2022? Unlike our other recommended treatments, which stop the infection and let your nail grow out, Canespro (from the makers of Canesten) lets you take a sledgehammer to the infected nail. Well, a scraper. It is a bit of a faff, but very powerful. First, you have to clean and soften the affected foot (or hand) in warm water, dry it, apply the ointment and cover it all with a plaster. You do this once a day. After the first 24 hours, you can start scraping at the infected nail tissue, which will start to come away. After a couple of weeks of this fun, you’ll have removed the entire infected nail. Plasters and a scraper are included in the box. It’s not a subtle approach (and you’ll need to take care not to get the ointment on healthy skin), but if you want to get rid of the infection fast then this is the best choice. Check out the official instruction video on YouTube. Find extra details at best toenail fungus treatment.

This dermatologically tested anti-fungal soap helps to prevent nail fungal infections by using a concentrated blend of natural and organic ingredients that clean and moisturise your skin and nails. These ingredients include tea tree oil, aloe vera, rosemary, and mint, as well as jojoba, coconut, and olive oil. Not only does this soap help to prevent fungal nails, but it also helps with body odour, athlete’s foot, ringworm, jock itch, yeast infections, and more general skin irritations with the 100 percent natural formula. Using an innovative slow-release penetrative formula, Excilor Ultra Nail Fungus Treatment works over a 24-hour period to ensure the healthy re-growth of the nail. You won’t have to spend time filing down your nails with this treatment, as it can get through to the infection without it. This polish can also be used in conjunction with nail polish, so you can disguise the infection as you treat it.

The Arishine Toenail Treatment has the design and convenience of a pencil. Perfect for storing in a bag or pocket while at work, the repair pencil allows you to use a paintable nail polish on your infected toenail three times a day with ease to treat a nail fungal issue. The Arishine treatment uses two percent deacetylated chitin, three percent O-hydroxybenzoic acid, and Angelica dahurica as active ingredients to get rid of fungus and heal the damage. This solution can help treat discoloration, brittleness, split, rough, and cracked nails. Ultimately, this medicated nail polish can lead to stronger and healthier nails. Arishine is made of natural ingredients and does not conduct animal testing. Treatment requires three applications a day and should be used for four to 12 weeks, although improvement may be visible in as few as two weeks. Arishine offers customers a satisfaction guarantee.

The best fungal nail treatments work by killing the normally harmless spores that multiply in dark, swampy places such as between your toes (where they cause athlete’s foot) and in the beds of your nails. The result can be as painful as it is unsightly, but effective treatment is easy to use at home and can make a difference within weeks, leaving you free to wear those open-toed sandals with pride. Skip down the page to see which fungal nail treatments we recommend for clearing up infections fast, or read on for more tips about choosing the right treatment for you.

Toenail fungus is a common fungal condition that often starts after a rash on the foot spreads to the nails. When mild, it looks like white and yellow spots growing under the nail beds. If left untreated, the fungus can grow severely by hardening the nails and spreading to other toes. Lamisil Terbinafine Antifungal Cream treats fungus all over the body, including athlete’s foot, making it the best overall choice. The Fungi Nail Anti-Fungal Ointment is infused with five oils and makes for a budget-friendly option. We researched dozens of toenail fungus treatments and evaluated them based on the following attributes: cost, medication forms, ingredients, and treatment areas. Read extra information on toenail fungus treatment.

By Health